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Jen-Kun Lin Selected Research

pentagalloylglucose

8/2006Pentagalloylglucose inhibits estrogen receptor alpha by lysosome-dependent depletion and modulates ErbB/PI3K/Akt pathway in human breast cancer MCF-7 cells.
4/2004Induction of G1 arrest and apoptosis in human jurkat T cells by pentagalloylglucose through inhibiting proteasome activity and elevating p27Kip1, p21Cip1/WAF1, and Bax proteins.
6/2003Induction of G1 phase arrest in MCF human breast cancer cells by pentagalloylglucose through the down-regulation of CDK4 and CDK2 activities and up-regulation of the CDK inhibitors p27(Kip) and p21(Cip).

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Jen-Kun Lin Research Topics

Disease

37Neoplasms (Cancer)
09/2012 - 01/2002
16Breast Neoplasms (Breast Cancer)
09/2012 - 06/2003
7Carcinogenesis
04/2011 - 06/2002
6Melanoma (Melanoma, Malignant)
06/2008 - 10/2002
5Neoplasm Metastasis (Metastasis)
12/2011 - 06/2005
5Inflammation (Inflammations)
02/2011 - 01/2002
5Carcinoma (Carcinomatosis)
06/2007 - 04/2002
4Type 2 Diabetes Mellitus (MODY)
05/2015 - 08/2008
4Body Weight (Weight, Body)
07/2014 - 01/2005
4Hepatocellular Carcinoma (Hepatoma)
10/2012 - 01/2005
4Colorectal Neoplasms (Colorectal Cancer)
09/2005 - 10/2002
3Lung Neoplasms (Lung Cancer)
03/2014 - 01/2002
3Glioma (Gliomas)
06/2009 - 06/2005
3Prostatic Neoplasms (Prostate Cancer)
04/2009 - 07/2004
3Colonic Neoplasms (Colon Cancer)
09/2005 - 04/2003
2Insulin Resistance
02/2012 - 08/2008
2Obesity
02/2012 - 02/2006
2Leukemia
10/2004 - 01/2004
1Weight Loss (Weight Reduction)
07/2014
1Metabolic Syndrome (Dysmetabolic Syndrome X)
07/2014
1Hyperlipidemias (Hyperlipidemia)
02/2012
1Squamous Cell Carcinoma of Head and Neck
04/2011

Drug/Important Bio-Agent (IBA)

13TeaIBA
07/2014 - 01/2002
13Proteins (Proteins, Gene)FDA Link
02/2012 - 04/2002
7Fatty Acid Synthases (Fatty Acid Synthase)IBA
02/2012 - 07/2004
6PolyphenolsIBA
09/2008 - 01/2002
5CurcuminIBA
09/2012 - 02/2002
5Cytochromes c (Cytochrome c)IBA
03/2008 - 07/2003
5Propolis (Bee Bread)IBA
09/2007 - 01/2004
5CaspasesIBA
11/2005 - 07/2003
4Caspase 3 (Caspase-3)IBA
09/2012 - 01/2005
4CarcinogensIBA
04/2011 - 07/2004
4NF-kappa B (NF-kB)IBA
06/2009 - 01/2005
3Insulin (Novolin)FDA Link
07/2014 - 08/2008
3garcinolIBA
03/2014 - 04/2005
3Epidermal Growth Factor (EGF)IBA
06/2011 - 01/2007
3PENTAIBA
04/2009 - 10/2002
3beta-d-glucoseIBA
04/2009 - 10/2002
3Transcription Factor AP-1 (Transcription Factor AP 1)IBA
10/2008 - 10/2002
3propolin AIBA
01/2007 - 04/2003
3pentagalloylglucoseIBA
08/2006 - 06/2003
3Phosphotransferases (Kinase)IBA
12/2005 - 04/2003
3Cyclin-Dependent Kinases (cdk Proteins)IBA
04/2004 - 10/2002
3DNA (Deoxyribonucleic Acid)IBA
01/2004 - 10/2002
2LipidsIBA
07/2014 - 12/2005
2Glucose (Dextrose)FDA LinkGeneric
07/2014 - 08/2008
2Protein Kinase CIBA
02/2012 - 07/2004
2Messenger RNA (mRNA)IBA
12/2011 - 01/2005
2Estrogen ReceptorsIBA
06/2011 - 08/2006
2Focal Adhesion Protein-Tyrosine KinasesIBA
04/2011 - 06/2008
2FlavonoidsIBA
08/2010 - 01/2008
2Matrix Metalloproteinases (MMPs)IBA
04/2009 - 01/2005
2AndrogensIBA
04/2009 - 07/2004
2epigallocatechin gallate (epigallocatechin-3-gallate)IBA
12/2008 - 08/2008
2Estrogens (Estrogen)FDA Link
12/2008 - 08/2006
2Reactive Oxygen Species (Oxygen Radicals)IBA
03/2008 - 11/2005
2Androgen Receptors (Androgen Receptor)IBA
01/2008 - 07/2004
2LuteolinIBA
01/2008 - 07/2007
2Paclitaxel (Taxol)FDA LinkGeneric
12/2007 - 06/2002
2Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
06/2007 - 02/2004
2theaflavinIBA
01/2007 - 01/2002
2p38 Mitogen-Activated Protein KinasesIBA
01/2007 - 06/2005
2tangeretinIBA
01/2007 - 10/2002
2propolin BIBA
01/2007 - 01/2004
2Sulfhydryl Compounds (Thiols)IBA
01/2007 - 07/2004
2Oxidants (Oxidizing Agents)IBA
01/2007 - 07/2004
2ZincIBA
01/2007 - 07/2004
2Hormones (Hormone)IBA
08/2006 - 09/2004
2CholesterolIBA
02/2006 - 01/2005
2Triglycerides (Triacylglycerol)IBA
02/2006 - 01/2005
2Tyrosine (L-Tyrosine)FDA Link
12/2005 - 09/2005
2AntioxidantsIBA
06/2005 - 01/2004
2ApigeninIBA
01/2005 - 02/2004
2theaflavin-3,3'-digallateIBA
07/2004 - 01/2002
2Cyclin D3IBA
07/2003 - 04/2002
1CarbohydratesIBA
05/2015
1Blood Glucose (Blood Sugar)IBA
05/2015
1AcarboseFDA LinkGeneric
05/2015
16-pyruvoyltetrahydropterin synthase (PTPS)IBA
05/2015
1Glycoside Hydrolase InhibitorsIBA
05/2015
1bufalinIBA
10/2012
1PalmitatesIBA
02/2012
1FructoseIBA
02/2012
1Nonesterified Fatty Acids (NEFA)IBA
02/2012
1Matrix Metalloproteinase 2 (Gelatinase A)IBA
12/2011
1Docetaxel (Taxotere)FDA Link
12/2011
1F-Box ProteinsIBA
06/2011
1S-Phase Kinase-Associated Proteins (Skp1 Protein)IBA
06/2011
1Matrix Metalloproteinase 9 (Gelatinase B)IBA
04/2011
1VimentinIBA
04/2011
1arecoline 1-oxideIBA
04/2011
1EnzymesIBA
02/2011
1epicatechin gallateIBA
02/2011
1Transcription Factors (Transcription Factor)IBA
02/2011
1Antineoplastic Agents (Antineoplastics)IBA
08/2010
1RotenoneIBA
02/2010

Therapy/Procedure

10Chemoprevention
09/2012 - 01/2002
2Therapeutics
04/2011 - 09/2004
2Drug Therapy (Chemotherapy)
06/2002 - 04/2002
1Oral Administration
05/2015